Since its inception in 1995, SPLIT steadily grew into an established collaborative, integrated infrastructure and community with synergistic platforms in research, education, patient advocacy, mentorship, quality improvement and clinical care. Over the years, SPLIT’s primary goal of improving outcomes for children who have undergone liver transplantation were powered via pharmaceutical (SPLIT 1.0), United States National Institutes of Health Grant (SPLIT 2.0), and self-funded (SPLIT 3.0) strategies. As the SPLIT Executive Council looked toward the future, it became clear that joining forces with a self-governing society with vast administrative and infrastructural support such as TTS would ensure the next chapter of SPLIT (4.0) to achieve and excel in our targeted mission to improve the lives of children who require liver transplantation.