Solid organ transplants are life-changing experiences that impact recipients, donors, care partners, medical teams, communities, and popular media. Social media is an influential part of modern life and provides a platform for healthcare experiences. This study assessed perspectives on solid organ transplantation by exploring the transplant community’s utilization of the social media site Reddit.

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Von Willebrand factor (VWF) is a procoagulant glycoprotein expressed exclusively in endothelial cells and megakaryocytes. It mediates platelet adhesion to endothelial/subendothelial surfaces and initiates thrombogenesis. External stimuli, including hypoxia, were shown to upregulate VWF expression levels and alter its vascular tree expression pattern in the lung. Increased VWF levels are a significant risk factor for thrombus formation, a major complication in organ transplantation. Given that donor organs experience hypoxic conditions during transplantation, this study investigates whether hypoxia alters VWF expression and whether modifying organ preservation to reduce hypoxic exposure could prevent these alterations.

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