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Transplantation Journal November Issue

The November issue of the Transplantation offers a broad, most relevant and exciting collection of manuscripts

Overview

  • Robotic Surgery is getting increasingly relevance for donor and transplant procedures. Indications, challenges, advantages and educational aspects are presented in an Expert Insight contribution by Elizabeth Pomfret representing the perspective of a ‘Non-robotic surgeon’.
  • With many organs currently procured but not utilized for transplantation, understanding refusal patterns is of critical importance. Refusal patterns based on patient, center and organ patterns are analyzed based on most recent Organ Procurement and Transplantation Network data, providing a framework to improve organ allocation.
  • Liver re-transplantation remains a challenging indication. Based on the SRTR data a user-friendly online application is introduced using recipient and donor characteristics to predict 1-year survival. This tool may may support the decision to list candidates while guiding donor selection.
  • And....the first report non-US program report on more than 1,000 pancreas transplants coming from Sao Paulo, Brazil.

This is just a small selection of outstanding contributions. Enjoy the November issue of Transplantation.

Table of Contents

In View

Expert Insight

Robotic Surgery in Living Donor Hepatectomy and Liver Transplantation: A Critical Analysis From a Nonrobotic Surgeon’s Perspective
Elizabeth A. Pomfret

The Necessity of Brain Blood Flow Testing in Thoracoabdominal Normothermic Regional Perfusion
Christos Lazaridis, Rafael Badenes, John P. Lizza, Elizabeth Carroll, Tracey Fan, William Roth, Michael A. Rubin, William F. Parker, James L. Bernat

Game Changer

Clinical Xenogeneic Heart Transplantation: Lessons From the Second Patient
Asghar Ali, Eckhard Wolf, Bruno Reichart

Research Highlights

Research Highlights
Nadia Chandra Sekar, Natasha M. Rogers

Commentaries

Pancreas Preservation: Are We Getting Warmer With Normothermic Ex Vivo Perfusion?
Jeevan Prakash Gopal, Anand S.R. Muthusamy, Vassilios E. Papalois, Frank J.M.F. Dor

Liver Retransplantation—Can We Predict Futility?
Arpit Amin, James V. Guarrera, Keri E. Lunsford

Metabolic Crosstalk in Steatotic Grafts: Pyruvate Kinase M2 as a Fibrogenic Switch in Allograft Fibrosis
Frederik Schliephake, Deniz Uluk, Zoltan Czigany

Equity Is Everyone’s Business
Lorna P. Marson

Beyond Histology: A Single-cell Perspective on Intestinal Transplantation
Alexander Kroemer

Reviews

Management of the Acute Liver Failure Patient and the Role of Liver Transplantation
Constantine J. Karvellas, Florent Artru, Audrey Coilly, Isabel Conde Amiel, Anil Dhawan, Ahmet Gurakar, Akila Rajakumar, Nazia Selzner, Ram Subramanian, Li-Ying Sun, Priya Walabh, Xuchen Zhang, Fuat H. Saner, on behalf of the International Liver Transplant Society—Acute Liver Failure Special Interest Group Steering Committee

Bioartificial Hearts, Assist Devices, and Myocardium: New Developments
Patricia Castellanos Vaquero, Anastasiya Rozenbaum, Maria Rocchi, Maziar Arfaee, Paul F. Gründeman, Jolanda Kluin

Clinical Manifestation, Mechanisms, and Potential Targets of Intervention for Chronic Rejection in Vascularized Composite Allotransplantation
Gerald Brandacher, Franka Messner, Yaser Al-Salmay, Christina L. Kaufman

Chronic Graft-versus-host Disease, Part 1: How Preclinical Models Shape Our Understanding of Biology and Pave the Way for Future Therapeutic Interventions
Christina R. Hartigan, Cameron McDonald-Hyman, Steven Z. Pavletic, Bruce R. Blazar

Original Basic Science

Normothermic Ex Vivo Machine Perfusion Mitigates Apoptosis in a Porcine Model of Pancreas Transplantation
Catherine Parmentier, Samrat Ray, Masataka Kawamura, Laura I. Mazilescu, Emmanuel Nogueira, Christian Hobeika, Francisco Calderón-Novoa, Tunpang Chu, Sujani Ganesh, Bhranavi Arulratnam, Sangeetha N. Kalimuthu, Laura Martínez-Arenas, Markus Selzner, Trevor W. Reichman

Progressive Hyperglycemia in Tolerant Miniature Swine Recipients of Composite Islet-kidney Grafts Is not due to Islet Loss but Rather to Increased Insulin Demand With Growth
Ishit Chauhan, Nathaly P. Llore, Atsushi Hirakata, Yoshinori Ishikawa, Prashanth Vallabhajosyula, Joshua Weiner, Kazuhiko Yamada, David H. Sachs, Adam Griesemer

PKM2 Drives Lactate-mediated Fibrosis in Liver Transplantation
Jun-yan Liu, Wei Liao, Zi-yan Chen, Tao Liu, Rui Wang, Jian-ping Gong, Xue-song Xu, Hao Wu

Original Clinical Science—Liver

Current Status of Minimally Invasive Surgery for Donor Hepatectomy: A Worldwide Survey (A Joint Initiative of the International Laparoscopic Liver Society and the International Living Donor Liver Transplantation Group)
Roberto Ivan Troisi, Mariano Cesare Giglio, Jongman Kim, Dieter Broering, Daniel Cherqui, Go Wakabayashi, Catherine Teh, Mohammed Abu-Hilal, Kwang-Woong Lee, Avi Soin, Jan Lerut, Chung-Ngai Tang, Luca Aldrighetti, Paulo Hermann, Horacio Asbun, Mohammed Rela, Ki Hun Kim, Susumu Eguchi, Ho-Seong Han, Kyung-Suk Suh, Mureo Kasahara, Kim Olthoff, David Geller, Hiroto Egawa, The World Survey on Minimally Invasive Donor Hepatectomy Collaboration Group

Perioperative Antibiotic Strategies in Liver Transplantation: A Propensity Score Analysis of Prophylaxis Versus Preemptive Therapy
Alexandre Elbaz, Clément Pesquet, Mylène Defaye, Marie-Charlotte Delignette, Cyrielle Despres, Robin Sakek, Emmanuel Weiss, Anne Bignon, Pauline Devauchelle, Antoine Dewitte

Liver Retransplantation: Identifying Factors and Developing a Risk Prediction Model to Predict Futility in the Modern Era
Daniel Waller, Srinath Chinnakotla, Karthik Ramanathan, Jessica Brierton, Sankhya Chintakrinda, Daniel Kuehler, Abraham Matar, Matthew Wright, David M. Vock, Vanessa Humphreville

Original Clinical Science—General

Insights From Refusal Patterns for Deceased Donor Kidney Offers
Grace Guan, Sanjit Neelam, Joachim Studnia, Xingxing S. Cheng, Marc L. Melcher, Michael A. Rees, Alvin E. Roth, Paulo Somaini, Itai Ashlagi

Over 1000 Pancreas Transplants in a Latin American Program
Marcelo Perosa, Juan R. Branez, Fernanda R. Danziere, Beimar Zeballos, Leonardo T. Mota, Ana C. Vidigal, Celia Watanabe, Caio C. Fonseca, Tiago G. Miranda, Adriana B. Bortoluzzo, Maria K. Venezuela, Leon Alvim, Tércio Genzini

Combined Heart and Liver Transplantation in the Failing Fontan: Systematic Review and Single-arm Meta-analysis
Vanessa Karlinski Vizentin, Vanio Antunes, Iuri Ferreira Felix, Cynthia Florencio de Mesquita, Elísio Bulhões, Rebecca K. Ameduri, Jonathan N. Johnson

Insights in Cellular and Molecular Signatures of the Small Intestinal Graft Posttransplantation: Successful, Recovered, and Rejected—A Case Series
Naomi Karmi, Roy Oelen, Emilia Bigaeva, Sofie de Jong, Jan Willem Haveman, Frans van der Heide, Marcela A. Hermoso, Monique G.P. van der Wijst, Gursah Kats-Ugurlu, Rinse K. Weersma, Eleonora A.M. Festen, Werna T.C. Uniken Venema, Gerard Dijkstra, on behalf of the TransplantLines Investigators

Regional and Gender Disparities in Abstracts Presented at the International Transplant Congresses
Isabelle Ethier, Kathleen Gaudio, Diya Nijjar, Sabrina Ramdane, Seokhwan Tommy Kim, Maggie Kam-Man Ma, Katya Loban, Chloe Wong-Mersereau, Marcelo Cantarovich, Shaifali Sandal

Letters

IVIg and FFP in Xenotransplantation: The Case for Product-specific Antibody Screening
Hidetaka Hara, Takayuki Yamamoto, David K.C. Cooper

Predicting Cytomegalovirus Infection in Seropositive Lung Transplant Recipients: How to Improve the Predictive Performance?
Zhi-Qiang Deng, Hao-Ji Yan, Dong Tian

Response to Letter: Global Immune Biomarkers and Donor Serostatus Can Predict Cytomegalovirus Infection Within Seropositive Lung Transplant Recipients
Bradley J. Gardiner, Sue J. Lee, Gregory I. Snell, Glen P. Westall, Anton Y. Peleg

 

Discover how social media is reshaping the world of transplantation — from global reach to everyday clinical impact.

Join us for Transplantation and Social Media: From Global Impact to Personal Practice.

October 29 | 11:00 EST (see details for local times)
#Transplantation #SocialMedia @TTS.org @TXPDirect @TransplantJrnl
CLICK HERE FOR DETAILS AND TO REGISTER

Transplantation Journal - Social Media Content

Engaging Brain Anti-inflammatory Circuits to Improve the Viability of Transplanted Organs
Solid organ transplantation is a life-saving intervention for tens of thousands of patients each year in the United States. A major underlying pathophysiologic process limiting the success of transplantation is inflammation. Since the first transplant >70 y ago, advancements in the fields of surgery and immunosuppression have improved both organ and patient survival. However, inflammation and its damaging effects remain the principal clinical problem limiting enduring organ transplant survival.
Read More
Safety and Tolerability of Sotagliflozin Among Kidney Transplant Recipients
Sodium-glucose cotransporter inhibitors (SGLTi) slow chronic kidney disease progression and reduce kidney failure events. Kidney transplant recipients (KTRs) remain at high risk for these outcomes. SGLTi cause an initial and sustained decline in estimated glomerular filtration rate (eGFR) and have a higher risk of urogenital infection, both of which are major concerns for KTRs. We sought to (1) assess the reversibility of eGFR changes and (2) explore safety and tolerability using sotagliflozin, a dual SGLT1/2 inhibitor.
Read More

Transplantation Direct - Social Media Content

Identification of Surrogate Outcome Biomarkers in Lung Allograft Recipients With Bronchiolitis Obliterans: Implications for Randomized Controlled Trials
We developed a prospective, multicenter “registry” to evaluate the effect of extracorporeal photopheresis for lung transplant recipients who develop chronic lung allograft dysfunction (CLAD) with the bronchiolitis obliterans syndrome (BOS) phenotype (CLAD/BOS) and who are refractory to conventional standard-of-care therapy.
READ MORE
Potential Impact of Extracorporeal Photopheresis on Trained Immunity and Organ Transplant Acceptance
Extracorporeal photopheresis (ECP) is a well-established, safe, and effective immunomodulatory therapy currently used in clinics to decrease T cell–mediated immunity in various disorders, including autoimmune diseases and chronic rejection in organ transplantation. Although the ECP procedure has been shown to induce apoptotic cells that are reintroduced into the patient at the end of the treatment, the precise tolerogenic mechanisms mediated by ECP are not fully understood.
READ MORE

Upcoming Webinar Presentations

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ISN-TTS Fellowship Awardee

The International Society of Nephrology (ISN) and TTS join forces to support the training of young physicians from low resource areas receiving hands-on training in advanced host institutions to acquire state of-the-art knowledge in transplantation. The ultimate goal of such training is to improve the transplantation standards in their home countries upon their return and become leaders in their fields. The training focuses on providing the skills and knowledge specifically required by the home institution. ISN-TTS Fellowship trainings can be long (6-12 months) or short term (3-6 months).

Siti Hafizah Mohammad Ismail, Malaysia

Will train at Royal Adelaide Hospital, Australia
Bio
Click here for more details about the program

International Pediatric Transplant Association Newsletter

Click here to read

TTS-ISODP-ESOT - The INTEGRITY Project

The consultation will close 31st October, 2025

Click here To learn more or contribute your feedback

Help Shape Ethical Standards in Deceased-Donation Research: The INTEGRITY Project – Public Consultation Open until October 31, 2025

The Transplantation Society (TTS) is partnering with the European Society of Transplantation (ESOT) and the International Society for Organ Donation Professionals (ISODP) to develop ethical guidelines for research involving deceased organ and tissue donation. The project aims to build global agreement on how such research should be carried out to improve transplant outcomes and save lives, while respecting ethical principles.

A draft version of the guidelines is now open for public consultation. Healthcare professionals, donor families, transplant recipients, and interested members of the public are all invited to provide input. The guidelines are available in multiple languages to assist engagement from around the world.

MESOT 2025 - 50th Anniversary of Organ Transplantation in Turkey

The 19th Congress of the MESOT has a very special meaning for us as at the same time, we will be celebrating the 50th Anniversary of Organ Transplantation in Turkey. It was on November 3, 1975 that our team performed the first successful living related kidney transplantation in Turkey from a mother to her 12-year-old son at Hacettepe University Hospitals.
At MESOT 2025, TTS expertise is front and center. The Pre-Congress Workshop—led by Prof. Mehmet Haberal with course chairs Marcelo Cantarovich and Andrea Herrera-Gayol—features a distinguished faculty including Jeremy Chapman, John Fung, Annika Tibell, Stefan Tullius, Andreas Tzakis, and Marti Manyalich. Across the main program, TTS leaders shape sessions and committees spanning ethics/education, kidney and liver transplantation, immunology, and registries, underscoring TTS’s impact on science, clinical practice, and governance. The agenda also includes a dedicated DICG (Declaration of Istanbul) ethics session focused on combating organ trafficking and advancing equitable practice.
View the Program
www.mesot2025.com

2025 Advancing Diversity, Equity & Inclusion in Transplantation Conference - October 25-26

It is our great pleasure to invite you to attend the 2025 Advancing Diversity, Equity & Inclusion in Transplantation: A Global Perspective Conference, taking place October 25 - 26, 2025 in Toronto, Ontario. This second edition will be co-located with the 6th Congress of International Advanced HBP Surgery (ISLS 2025).

Students, Trainees, Allied Health Professional, and Community members or patients save with special rates and hotel discount. DEI in Transplant registrants also receive a 15% discount for ISLS 2025.

Follow #DEIinTransplant2025 on social media:
x.com/DEIinTransplant
www.linkedin.com/company/deiintransplant
CLICK HERE FOR COMPLETE DETAILS AND TO REGISTER

2025 Donate Life Egypt Congress - November 12-15

Join us for the International Transplant Congress of Donate Life Egypt (DLE 2025) and be part of one of the leading global meetings in transplantation!

Donate Life Egypt (DLE) represents all professionals involved in transplantation in Egypt. It includes surgeons, hepatologists, nephrologists, anesthetists, pediatricians, radiologists, pathologists, specialists in infectious diseases, pharmacists, nutritionists, transplant coordinators and nurses. DLE is the professional voice of organ transplantation in Egypt providing leadership, representation, and guidance for the benefit of our patients.

CLICK HERE FOR COMPLETE DETAILS AND TO REGISTER

Asian Transplantation Week 2025 (ATW 2025) - November 20-22

Since its international expansion in 2016, ATW has continued to evolve as a leading platform for transplantation professionals across the Asia-Pacific region. Each year, the congress has seen remarkable growth both in scale and in the quality of its scientific content.

This year, under the theme “Together for Innovation: Breaking Boundaries in Asian Transplantation” ATW 2025 is set to offer a dynamic and forward-looking scientific program. It will bring together global experts to share emerging insights, debate pressing challenges, and foster meaningful dialogue across diverse areas of transplantation.

CLICK HERE FOR COMPLETE DETAILS AND TO REGISTER

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